Performance of Self-excited Energy Harvesters with Tip Bodies of Non-circular Cross Section Shapes

An experimental study on the performance of self-excited energy harvesters with non-circular tip body shapes has been performed. The two tip body shapes analyzed correspond to a half cylinder and a square cross section. Experiments are carried out in the wind tunnel to record the voltage output of the harvesters at different free stream velocities. The presence of the aeroelastic galloping instability was detected by the behavior of the transversal tip displacement of the harvester as well as the coupling of the motion and shedding frequency from the bluff body. The effect of tip mass, free stream turbulence, tip body shape, and localized stiffness is also studied. The parameter used to evaluate the performance of the energy harvester is the average power generated at every single case tested

Una herramienta de control de transitorios en canales de regadío

[ES] El problema de ajustar los caudales suministrados por un canal en lámina libre a los caudales demandados por los regantes en determinados puntos de derivación del canal requiere cierta capacidad de maniobra del canal y también necesita del estudio de transitorios. Se presenta un algoritmo de control en lazo abierto del flujo en lámina libre en canales basado en técnicas computacionales de optimización de problemas en régimen no estacionario que permite, conocidas las demandas de riego en un periodo de tiempo dado, definir los movimientos de todas las compuertas del canal para cumplir con el caudal deseado y en el instante requerido, optimizando así el aprovechamiento de los volúmenes de agua. Finalmente, se ilustra su utilización resolviendo dos problemas clásicos en el control de canales.Soler Guitart, J.; Gomez Valentin, M.; Rodellar Benedé, J. (2004). Una herramienta de control de transitorios en canales de regadío. Ingeniería del agua. 11(3):297-313. https://doi.org/10.4995/ia.2004.2539OJS297313113Clemmens, A.J., Kacerek, T.F., Grawitz, B., Schuurmans, W., (1998), "Test cases for canals control algorithms, Journal of Irrigation and Drainage", ASCE pp. 23-30.Clark, I.F., (1972), "Automatic Control of Canals", VIII Congress of ICID, Q.28.2.R.1, VarnaClemmens, A.J., Replogle J.A., (1989), "Control of irrigation canal networks", J. of Irrig. and Drain., ASCE, num.115(1), 96-110.Fletcher, R., (1987), Practical Methods of Optimization, 2nd. Ed., John Viley & Sons, U.K.Gill, P.E., Murray, W., Wright, M.H., (1981), Practical Optimization, Academic Press Inc., Scotland.Gómez, M., (1988), Contribución al estudio del movimiento variable en lámina libre en las redes de alcantarillado, Tesis doctoral UPC, Catalunya.Goussard, J., (1993), Automation of Canal Irrigation Systems, Int. Com. on Irrig. and Drain. (ICID), New Delhi.Krandall, S.H., (1956), Engineering Analisys-A Survey of Numerical Procedures, McGraw-Hill, New York.Liria, J., (2001), Canales hidráulicos. Proyecto, construcción, gestión y modernización, Col. Ing.de Cam., Can. y Puertos, Madrid.Luemberger, D.G., (1984), Linear and Nonlinear Programming, 2nd. Ed., Addison-Wesley, Massachusetts, US.Martín-Sánchez, J.M., Rodellar, J., (1996), Adaptive Predictive Control: from the concepts to plan optimization. Series in Systems and Control Engineering, Prentice Hall.Ministerio de Industria y Medio Ambiente, (1998), El Libro Blanco del Agua en España.Soler, J., (2003), "Contribució a l'estudi del control de canals de regadiu per mitjà de mètodes numèrics de programació no lineal. Aplicació al càlcul de les trajectòries de referencia", Tesis doctoral UPC, Catalunya

Closed-loop compensation of dielectric charge induced by ionizing radiation

This letter investigates the capability of dielectric charge control loops to cope with charge induced by ionizing radiation. To this effect, an microelectromechanical systems (MEMS) variable capacitor has been irradiated with X-rays and gamma-radiation in three scenarios: 1) without polarization; 2) using an open-loop dielectric charge mitigation strategy; and 3) using a closed-loop control method. The results show that the charge effects induced by radiation can be partially compensated using dielectric charge control.Peer ReviewedPostprint (author's final draft

5G New Radio for Terrestrial Broadcast: A Forward-Looking Approach for NR-MBMS

"© 2019 IEEE. Personal use of this material is permitted. Permissíon from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertisíng or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works."[EN] 3GPP LTE eMBMS release (Rel-) 14, also referred to as further evolved multimedia broadcast multicast service (FeMBMS) or enhanced TV (EnTV), is the first mobile broadband technology standard to incorporate a transmission mode designed to deliver terrestrial broadcast services from conventional high power high tower (HPHT) broadcast infrastructure. With respect to the physical layer, the main improvements in FeMBMS are the support of larger inter-site distance for single frequency networks (SFNs) and the ability to allocate 100% of a carrier's resources to the broadcast payload, with self-contained signaling in the downlink. From the system architecture perspective, a receive-only mode enables free-to-air (FTA) reception with no need for an uplink or SIM card, thus receiving content without user equipment registration with a network. These functionalities are only available in the LTE advanced pro specifications as 5G new radio (NR), standardized in 3GPP from Rel-15, has so far focused entirely on unicast. This paper outlines a physical layer design for NR-MBMS, a system derived, with minor modifications, from the 5G-NR specifications, and suitable for the transmission of linear TV and radio services in either single-cell or SFN operation. This paper evaluates the NR-MBMS proposition and compares it to LTE-based FeMBMS in terms of flexibility, performance, capacity, and coverage.This work was supported in part by the European Commission through the 5G-PPP Project 5G-Xcast (H2020-ICT-2016-2 call) under Grant 761498.Gimenez, JJ.; Carcel, JL.; Fuentes, M.; Garro, E.; Elliott, S.; Vargas, D.; Menzel, C.... (2019). 5G New Radio for Terrestrial Broadcast: A Forward-Looking Approach for NR-MBMS. IEEE Transactions on Broadcasting. 65(2):356-368. https://doi.org/10.1109/TBC.2019.291211735636865

From famine foods to delicatessen: Interpreting trends in the use of wild edible plants through cultural ecosystem services

TheMillenniumEcosystemAssessment found a general decline in the consumption and gathering of wild edible plants, but some studies also observe a localized increase. Using information frominterviews (n=1133) in seven sites in the Iberian Peninsula and one in the Balearic Islands,we 1) identify current trends in the consumption and gathering ofwild edible plants (n=56 plant-uses) and 2) analyze howcultural ecosystemservices relate to such trends. Our data show a generalized decrease in the consumption and gathering of wild edible plants, although the trend changes significantly across plant-uses. Specifically, we found that –despite the overall decreasing trend– uses of wild edible plants that simultaneously relate to foods with high cultural appreciation and the recreational function of gathering remain popular. Our results signal that cultural services and values associated to the gathering and consumption of some wild edible plants are important factors explaining divergent trends across plant species. This finding reinforces the notion that cultural ecosystem services are deeply intertwined with other categories of services which can combine in complex, non-linear ways producing a variety of interdependent benefits

Identification of Myocardial Insulin Resistance by Using Liver Tests: A Simple Approach for Clinical Practice

Cardiovascular risk; Myocardial insulin resistance; Non-alcoholic fatty liver diseaseRiesgo cardiovascular; Resistencia a la insulina del miocardio; Enfermedad del higado graso no alcoholicoRisc cardiovascular; Resistència a la insulina del miocardi; Malaltia del fetge gras no alcohòlicBackground: We report that myocardial insulin resistance (mIR) occurs in around 60% of patients with type 2 diabetes (T2D) and was associated with higher cardiovascular risk in comparison with patients with insulin-sensitive myocardium (mIS). These two phenotypes (mIR vs. mIS) can only be assessed using time-consuming and expensive methods. The aim of the present study is to search a simple and reliable surrogate to identify both phenotypes. Methods: Forty-seven patients with T2D underwent myocardial [18F]FDG PET/CT at baseline and after a hyperinsulinemic–euglycemic clamp (HEC) to determine mIR were prospectively recruited. Biochemical assessments were performed before and after the HEC. Baseline hepatic steatosis index and index of hepatic fibrosis (FIB-4) were calculated. Furthermore, liver stiffness measurement was performed using transient elastography. Results: The best model to predict the presence of mIR was the combination of transaminases, protein levels, FIB-4 score and HOMA (AUC = 0.95; sensibility: 0.81; specificity: 0.95). We observed significantly higher levels of fibrosis in patients with mIR than in those with mIS (p = 0.034). In addition, we found that patients with mIR presented a reduced glucose uptake by the liver in comparison with patients with mIS. Conclusions: The combination of HOMA, protein, transaminases and FIB-4 is a simple and reliable tool for identifying mIR in patients with T2D. This information will be useful to improve the stratification of cardiovascular risk in T2D.This work was supported by the Carlos III Health Institute and the European Regional Development Fund (PI16/02064, PI20/01588) and the Agency for Management of University and Research Grants (AGAUR) of Catalonia (2017SGR1303)

Occupational exposure to pesticides and endometrial cancer in the Screenwide case-control study

Background: Endometrial cancer is the most common gynaecological tumour in developed countries and disease burden is expected to increase over the years. Identifying modifiable risk factors may help developing strategies to reduce the expected increasing incidence of these neoplasms. Objective: This study evaluates the association between occupational exposure to pesticides and endometrial cancer using data from a recent case-control study in Spain. Methods: The analyses included data from 174 consecutive incident endometrial cancer cases and 216 hospital controls frequency-matched by age. Data were collected through structured epidemiological questionnaires and exposure to pesticides was assessed using a Spanish job-exposure matrix (MatEmESp). Results: Overall, 12% of controls and 18% of cases were occupationally exposed to pesticides. We observed a positive association between occupational exposure to pesticides and endometrial cancer (OR = 2.08; 95% CI = 1.13-3.88 compared to non-exposed). In general, exposures that occurred farther in the past were significantly associated with endometrial cancer. Exposure to insecticides, fungicides and herbicides were positively associated with endometrial cancer (OR = 2.08; 95% CI = 1.13-3.88, OR = 4.40; 95% CI = 1.65-13.33, and OR = 5.25; 95% CI = 1.84-17.67, respectively). The agricultural, poultry and livestock activities scenario was associated with endometrial cancer (OR = 4.16; 95% CI = 1.59-12.32), while the cleaning exposure scenario was not (OR = 1.22; 95% CI = 0.55-2.67). Conclusions: Assessment of occupational exposure to pesticides assessed using a Spanish job-exposure matrix revealed a positive association with endometrial cancer. The elucidation of the role of pesticide compounds on endometrial cancer should shed a light on the aetiology of this tumour

Clinical and Sociodemographic Determinants of Adherence to World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Recommendations in Breast Cancer Survivors-Health-EpiGEICAM Study

Breast cancer (BC) survivors are advised to follow the WCRF/AICR cancer prevention recommendations, given their high risk of developing a second tumour. We aimed to explore compliance with these recommendations in BC survivors and to identify potentially associated clinical and sociodemographic factors. A total of 420 BC survivors, aged 31-80, was recruited from 16 Spanish hospitals. Epidemiological, dietary and physical activity information was collected through questionnaires. A 7-item score to measure compliance with the recommendations was built according to the 2018 WCRF/AICR scoring criteria. Standardized prevalences and standardized prevalence ratios of moderate and high compliance across participant characteristics were estimated using multinomial and binary logistic regression models. The mean score was 3.9 (SD: 1.0) out of 7 points. Recommendations with the worst adherence were those of limiting consumption of red/processed meats (12% of compliance, 95% CI: 8.2-15.0) and high fibre intake (22% of compliance, 95% CI: 17.6-27.0), while the best compliance was observed for the consumption of fruits and vegetables (73% of compliance, 95% CI: 69.2-77.7). Overall, adherence was worse in women with university education and in those with first-degree relatives with BC. This information may be of interest to design and implement personalized preventive measures adapted to the characteristics of these patients.This research was funded by the Fundación Científica Asociación Española Contra el Cancer (AECC) (Scientific Foundation of the Spanish Association against Cancer 2016). This article presents independent research. The views expressed are those of the authors and not necessarily those of the Carlos III Institute of Health.S

Predictors of outcome in a Spanish cohort of patients with Fabry disease on enzyme replacement therapy

Fabry disease may be treated by enzyme replacement therapy (ERT), but the impact of chronic kidney disease (CKD) on the response to therapy remains unclear. The aim of the present study was to analyse the incidence and predictors of clinical events in patients on ERT. Study design: Multicentre retrospective observational analysis of patients diagnosed and treated with ERT for Fabry disease. The primary outcome was the first renal, neurological or cardiological events or death during a follow-up of 60 months (24-120). Results: In 69 patients (42 males, 27 females, mean age 44.6±13.7 years), at the end of follow-up, eGFR and the left ventricular septum thickness remained stable and the urinary albumin: creatinine ratio tended to decrease, but this decrease only approached significance in patients on agalsidase-beta (242-128mg/g (p=0.05). At the end of follow-up, 21 (30%) patients had suffered an incident clinical event: 6 renal, 2 neurological and 13 cardiological (including 3 deaths). Events were more frequent in patients with baseline eGFR≤60ml/min/1.73m2 (log Rank 12.423, p=0.001), and this remained significant even after excluding incident renal events (log Rank 4.086, p=0.043) and in males and in females. Lower baseline eGFR was associated with a 3- to 7-fold increase the risk of clinical events in different Cox models. Conclusions: GFR at the initiation of ERT is the main predictor of clinical events, both in males and in females, suggesting that start of ERT prior to the development of CKD is associated with better outcomes

Evaluation of somatic mutations in cervicovaginal samples as a non-invasive method for the detection and molecular classification of endometrial cancer

Background The incidence of endometrial cancer is increasing worldwide. While delays in diagnosis reduce survival, case molecular misclassification might be associated with under- and over-treatment. The objective of this study was to evaluate genetic alterations to detect and molecularly classify cases of endometrial cancer using non-invasive samples. Methods Consecutive patients with incident endometrial cancer (N = 139) and controls (N = 107) from a recent Spanish case–control study were included in this analysis. Overall, 339 cervicovaginal samples (out of which 228 were clinician-collected and 111 were self-collected) were analysed using a test based on next-generation sequencing (NGS), which targets 47 genes. Immunohistochemical markers were evaluated in 133 tumour samples. A total of 159 samples were used to train the detection algorithm and 180 samples were used for validation. Findings Overall, 73% (N = 94 out of 129 clinician-collected samples, and N = 66 out of 90 self-collected samples) of endometrial cancer cases had detectable mutations in clinician-collected and self-collected samples, while the specificity was 80% (79/99) for clinician-collected samples and 90% (19/21) for self-collected samples. The molecular classifications obtained using tumour samples and non-invasive gynaecologic samples in our study showed moderate-to-good agreement. The molecular classification of cases of endometrial cancer into four groups using NGS of both clinician-collected and self-collected cervicovaginal samples yielded significant differences in disease-free survival. The cases with mutations in POLE had an excellent prognosis, whereas the cases with TP53 mutations had the poorest clinical outcome, which is consistent with the data on tumour samples. Interpretation This study classified endometrial cancer cases into four molecular groups based on the analysis of cervicovaginal samples that showed significant differences in disease-free survival. The molecular classification of endometrial cancer in non-invasive samples may improve patient care and survival by indicating the early need for aggressive surgery, as well as reducing referrals to highly specialized hospitals in cancers with good prognosis. Validation in independent sets will confirm the potential for molecular classification in non-invasive samples. Funding This study was funded by a competitive grant from Instituto de Salud Carlos III through the projects PI19/01835, PI23/00790, and FI20/00031, CIBERESP CB06/02/0073 and CIBERONC CB16/12/00231, CB16/12/00234 (Co-funded by European Regional Development Fund. ERDF: A way to build Europe). Samples and data were provided by Biobank HUB-ICO-IDIBELL, integrated into the Spanish Biobank Network, and funded by the Instituto de Salud Carlos III (PT20/00171) and by Xarxa de Bancs de Tumors de Catalunya (XBTC) sponsored by Pla Director d’Oncologia de Catalunya. This work was supported in part by the AECC, Grupos estables (GCTRA18014MATI). It also counts with the support of the Secretariat for Universities and Research of the Department of Business and Knowledge of the Generalitat de Catalunya, and grants to support the activities of research groups 2021SGR01354 and 2021SGR1112